Food enzymes · EFSA · 7 October 2026
Phospholipase A1 from strain LFC: the panel has no safety concern, the Commission has not listed the enzyme
On 7 October 2026 the EFSA Journal published the FEZ Panel opinion on phospholipase A1 from the non-genetically modified Fusarium commune strain LFC (doi:10.2903/j.efsa.2026.10341, EFSA-Q-2025-00643, applicant DSM Food Specialties B.V.). The draft was adopted on 8–9 September 2026, subject to editorial changes. It is a risk assessment of one preparation in two food processes, not a marketing authorisation.
The figures that belong in the supplier file are narrow. Dietary exposure in European populations was estimated at up to 0.432 mg total organic solids (TOS) per kg body weight per day. A 90-day rat study found no adverse effects up to 1124 mg TOS/kg bw/day, the highest dose tested. The margin of exposure is at least 2601. Genotoxicity tests raised no concern. In the Panel’s view the finished enzyme contains no viable cells of the production strain. Sequence identity with known allergens was not found; an allergic reaction cannot be excluded, and the Panel rates that likelihood as low.
Opinion versus listing
| Item | What e10341 says | What it does not allow |
|---|---|---|
| Identity | Phospholipase A1, EC 3.1.1.32, non-GM strain LFC, DSM Food Specialties B.V. | Transfer to another Fusarium strain, a GM preparation, or a trade name alone. |
| Scope | Two food manufacturing processes. Secondary reports do not name them; the count is what the opinion supports. | Adding bakery, dairy or a food supplement use that is not in this dossier. |
| Exposure | Up to 0.432 mg TOS/kg bw/day. | Treating 0.432 mg as a supplement dose or an NRV. |
| Toxicity | NOAEL 1124 mg TOS/kg bw/day; MoE at least 2601. | Quoting the MoE on a label as “2601 times safer”. |
| Legal status | Scientific opinion of 7 October 2026. | An entry on the Union list under Regulation 1332/2008. Until a Commission act, Article 17 and pre-20 January 2010 national law remain the transitional route, if the preparation falls within them at all. |
Glossary
- TOS
- Total organic solids of the enzyme preparation. The denominator of exposure in FEZ opinions, not a supplement label dose.
- MoE
- Margin of exposure. Here at least 2601 (1124 / 0.432). Not a label safety factor.
- Regulation 1332/2008
- The food enzymes regulation. Lawful use in the EU turns on the Union list and, until that list is fully operational, on Article 17.
What to do with the opinion
- Match the supplier specification to strain LFC, EC 3.1.1.32 and DSM Food Specialties B.V. Another strain code is another dossier.
- Keep the use inside the two processes assessed. Do not invent process names the 7 October secondary report does not give.
- Do not cite MoE 2601 as a permitted dose. Process safety is not a claim under Regulation 1924/2006.
- Keep batch traceability under Article 18 of Regulation 178/2002 and ask the supplier where the preparation sits against Article 17 of Regulation 1332/2008.
Sources
EFSA Panel on Food Enzymes (FEZ), Safety evaluation of the food enzyme phospholipase A1 from the non-genetically modified Fusarium commune strain LFC, EFSA Journal, 7 October 2026, doi:10.2903/j.efsa.2026.10341. Publication list: efsa.europa.eu/en/publications. Adoption at the 22nd FEZ plenary, 8–9 September 2026, minutes agreed 9 September 2026: FEZ minutes. Figures as reported on 7 October 2026 (0.432 mg TOS/kg bw/day, NOAEL 1124, MoE ≥ 2601, two processes): Cibum. Regulations (EC) No 1332/2008, 1331/2008 and 178/2002.
Not legal advice on a specific file. Supplemental.pl is the law firm. FOODLAW.ai is the tools platform. C.L.A.I.M.S. searches 2318 claims (2078 SANCO/11074/2013 on-hold plus 240 under Regulation 432/2012) and is not a Commission register.